Here are two exposures of the same Queen  Anne’s Lace, one at f16, one at f5. Slide the bar left and right to compare how the depth of field changes. This was shot with the Sony RX-10-V5 at 600mm equiv, close to minimum focus distance.

In this case the wide open aperture produces a much more impressive focus isolation than the f16, because the background greenery is pretty close to the main subject.

I often bracket from fully open to fully closed aperture because I find that I can only judge the best result later on a big screen.